Medicinal Chemistry

 

Medicinal chemistry in drug discovery:

  • bibliographic and IP research, analysis of patent environment
  • hit to lead work,
  • lead optimization,
  • small focused library sets (10-50 compounds),
  • interpretation of SAR and biological data,
  • Integrated medchem services including molecular modeling, physical and biological properties, early ADMET and pharmacokinetic studies, solubility screening… with preferred external partners,
  • ideas and implementation of nucleotide prodrug approaches,
  • proposition and initiation of back-up strategies,
  • custom synthesis that typically includes:
    • synthesis route scouting and design for mg to 50g
    • scale-up development with preferred external partners for 50g to Kg lab (GMP or non GMP)
    • synthesis of building blocks, scaffolds, intermediates, reference products, competitor compounds, metabolites, impurities…

 

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