Medicinal Chemistry
Medicinal chemistry in drug discovery:
- bibliographic and IP research, analysis of patent environment
- hit to lead work,
- lead optimization,
- small focused library sets (10-50 compounds),
- interpretation of SAR and biological data,
- medchem services with preferred external partners including molecular modeling, physical and biological properties, early ADMET and pharmacokinetic studies, solubility screening… ,
- ideas and implementation of nucleotide prodrug approaches,
- proposition and initiation of back-up strategies,
- custom synthesis that typically includes:
- synthesis of building blocks, scaffolds, intermediates, reference products, competitor compounds, metabolites, impurities…
- synthesis route scouting and design for mg to 20g